The recent observation that class VI myosins move in a direction opposite to all other known myosins, taken together with analyses of mutant flies and mice, suggests that, instead of moving vesicles out towards the cell periphery, myosin VI more likely brings materials or membranes into the cell.
Bibliographical noteFunding Information:
The author would like to thank Joe Kelleher for many stimulating discussions and for helpful comments on the review. M.A.T. is supported by grants from the National Institutes of Health, National Science Foundation, and the American Heart Association.