Cytoprotective properties of a fullerene derivative against copper

Tatsiana A. Ratnikova; Mark J. Bebber; George Huang; Lyndon L. Larcom; Pu Chun Ke

doi:10.1088/0957-4484/22/40/405101

Cytoprotective properties of a fullerene derivative against copper

Tatsiana A. Ratnikova, Mark J. Bebber, George Huang, Lyndon L. Larcom, Pu Chun Ke

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

To delineate the complexity of the response of cells to nanoparticles we have performed a study on HT-29 human colon carcinoma cells exposed first to a fullerene derivative C₆₀(OH)₂₀ and then to physiological copper ions. Our cell viability, proliferation, and intracellular reactive oxygen species (ROS) production assays clearly indicated that C ₆₀(OH)₂₀ suppressed cell damage as well as ROS production induced by copper, probably through neutralization of the metal ions by C ₆₀(OH)₂₀ in the extracellular space, as well as by adsorption and uptake of the nanoparticles surface-modified by the biomolecular species in the cell medium. This double-exposure study provides new data on the effects of nanoparticles on cell metabolism and may aid the treatment of oxidant-mediated diseases using nanomedicine.

Original language	English (US)
Article number	405101
Journal	Nanotechnology
Volume	22
Issue number	40
DOIs	https://doi.org/10.1088/0957-4484/22/40/405101
State	Published - Oct 7 2011
Externally published	Yes

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title = "Cytoprotective properties of a fullerene derivative against copper",

abstract = "To delineate the complexity of the response of cells to nanoparticles we have performed a study on HT-29 human colon carcinoma cells exposed first to a fullerene derivative C60(OH)20 and then to physiological copper ions. Our cell viability, proliferation, and intracellular reactive oxygen species (ROS) production assays clearly indicated that C 60(OH)20 suppressed cell damage as well as ROS production induced by copper, probably through neutralization of the metal ions by C 60(OH)20 in the extracellular space, as well as by adsorption and uptake of the nanoparticles surface-modified by the biomolecular species in the cell medium. This double-exposure study provides new data on the effects of nanoparticles on cell metabolism and may aid the treatment of oxidant-mediated diseases using nanomedicine.",

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T1 - Cytoprotective properties of a fullerene derivative against copper

AU - Ratnikova, Tatsiana A.

AU - Bebber, Mark J.

AU - Huang, George

AU - Larcom, Lyndon L.

AU - Ke, Pu Chun

PY - 2011/10/7

Y1 - 2011/10/7

N2 - To delineate the complexity of the response of cells to nanoparticles we have performed a study on HT-29 human colon carcinoma cells exposed first to a fullerene derivative C60(OH)20 and then to physiological copper ions. Our cell viability, proliferation, and intracellular reactive oxygen species (ROS) production assays clearly indicated that C 60(OH)20 suppressed cell damage as well as ROS production induced by copper, probably through neutralization of the metal ions by C 60(OH)20 in the extracellular space, as well as by adsorption and uptake of the nanoparticles surface-modified by the biomolecular species in the cell medium. This double-exposure study provides new data on the effects of nanoparticles on cell metabolism and may aid the treatment of oxidant-mediated diseases using nanomedicine.

AB - To delineate the complexity of the response of cells to nanoparticles we have performed a study on HT-29 human colon carcinoma cells exposed first to a fullerene derivative C60(OH)20 and then to physiological copper ions. Our cell viability, proliferation, and intracellular reactive oxygen species (ROS) production assays clearly indicated that C 60(OH)20 suppressed cell damage as well as ROS production induced by copper, probably through neutralization of the metal ions by C 60(OH)20 in the extracellular space, as well as by adsorption and uptake of the nanoparticles surface-modified by the biomolecular species in the cell medium. This double-exposure study provides new data on the effects of nanoparticles on cell metabolism and may aid the treatment of oxidant-mediated diseases using nanomedicine.

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Cytoprotective properties of a fullerene derivative against copper

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