Cytoprotective properties of a fullerene derivative against copper

Tatsiana A. Ratnikova, Mark J. Bebber, George Huang, Lyndon L. Larcom, Pu Chun Ke

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

To delineate the complexity of the response of cells to nanoparticles we have performed a study on HT-29 human colon carcinoma cells exposed first to a fullerene derivative C60(OH)20 and then to physiological copper ions. Our cell viability, proliferation, and intracellular reactive oxygen species (ROS) production assays clearly indicated that C 60(OH)20 suppressed cell damage as well as ROS production induced by copper, probably through neutralization of the metal ions by C 60(OH)20 in the extracellular space, as well as by adsorption and uptake of the nanoparticles surface-modified by the biomolecular species in the cell medium. This double-exposure study provides new data on the effects of nanoparticles on cell metabolism and may aid the treatment of oxidant-mediated diseases using nanomedicine.

Original languageEnglish (US)
Article number405101
JournalNanotechnology
Volume22
Issue number40
DOIs
StatePublished - Oct 7 2011

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