Cytoprotective effect of trimetazidine on 75 min warm renal ischemia-reperfusion injury in rats

A. Özden, Z. Aybek, N. Saydam, N. Çalli, O. Saydam, E. Düzcan, G. Güner

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

In this experimental study, we evaluated the effect of trimetazidine (TMZ) on renal ischemia-reperfusion (IR) injury in Sprague-Dawley rats. Renal IR was achieved by a 75-min clamping of the left renal pedicle and subsequent 24 h reperfusion, after right nephrectomy was performed. The rats were randomly divided into three groups: group 1 (sham operated: no IR injury), group 2 (ischemic control: saline treatment), and group 3 (3 mg/kg TMZ before ischemia). After 24 h of reperfusion, blood samples and renal tissue samples were taken to measure the levels of creatinine, tissue malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) activity. Histopathological changes were evaluated, In addition, the 7-day survival rates in each group were evaluated. We found significant increases in the levels of creatinine and tissue MDA, severe acute tubular necrosis, and a significant decrease in the activity of the GSH-Px in group 2. There were significant decreases in the levels of creatinine and tissue MDA, mild acute tubular necrosis, and a significant increase in activity of the GSH-Px in group 3 when compared with the control group (p < 0.05). Statistically significant differences (p < 0.05) in survival were noted between the ischemic control and sham-operated and TMZ groups. We have concluded that TMZ is able to protect the kidney from warm IR injury.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalEuropean Surgical Research
Volume30
Issue number4
DOIs
StatePublished - Jul 1 1998
Externally publishedYes

Keywords

  • Glutathione
  • Glutathione peroxidase
  • Ischemia-reperfusion injury
  • Malondialdehyde
  • Renal ischemia
  • Trimetazidine

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