Cytoplasmic dynein during mitosis

Edward H. Hinchcliffe, Kevin T. Vaughan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cytoplasmic dynein is a prominent microtubule (MT) motor protein that plays several crucial roles during mitosis. Although important contributions to spindle assembly, spindle positioning, and kinetochore function are well accepted, more recent discoveries into nuclear envelope breakdown, spindle assembly checkpoint silencing, and cortical anchoring have garnered attention. This chapter is focused on mechanisms of targeting to each location and the impacts of defects in this process on mitotic progression. Where appropriate, the relative contributions of dynein and other MT-binding proteins are compared.

Original languageEnglish (US)
Title of host publicationDyneins
Subtitle of host publicationThe Biology of Dynein Motors: Second Edition
PublisherElsevier Inc.
Pages535-555
Number of pages21
ISBN (Electronic)9780128097021
ISBN (Print)9780128094716
DOIs
StatePublished - Nov 22 2017

    Fingerprint

Keywords

  • Cytoplasmic dynein
  • Kinase
  • Kinetochore
  • Mitosis
  • Phosphorylation

Cite this

Hinchcliffe, E. H., & Vaughan, K. T. (2017). Cytoplasmic dynein during mitosis. In Dyneins: The Biology of Dynein Motors: Second Edition (pp. 535-555). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809471-6.00019-X