Cytomegalovirus infection in infancy: Virological and immunological studies

R. C. Gehrz, K. M. Linner, W. R. Christianson, A. E. Ohm, H. H. Balfour

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Immunological and virological studies on 18 infants with cytomegalovirus (CMV) infection were performed. Eleven of these infants were studied on multiple occasions over a period of 1 year. The patients were divided into three clinical groups based on the probable time of infection and the resulting variation in clinical presentation. General parameters of cell-mediated immunity as determined by E-rosette formation and lymphocyte proliferative responses to mitogens and antigens were found to be normal. Quantitation of CMV excretion in uine, CMV-specific immunofluorescent (IF) and complement-fixing (CF) antibody titres and CMV-specific cell-mediated immune responses were done on all patients at approximately monthly intervals. Throughout the study period all patients continued to excrete CMV despite the presence of high antibody titres to the virus. CMV-specific lymphocyte proliferation responses were absent or diminished in 15 of the 18 patients. The immunological and virological status of all patients was similar regardless of the clinical manifestation of infection.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalClinical and Experimental Immunology
Volume47
Issue number1
StatePublished - Feb 6 1982

Fingerprint Dive into the research topics of 'Cytomegalovirus infection in infancy: Virological and immunological studies'. Together they form a unique fingerprint.

  • Cite this

    Gehrz, R. C., Linner, K. M., Christianson, W. R., Ohm, A. E., & Balfour, H. H. (1982). Cytomegalovirus infection in infancy: Virological and immunological studies. Clinical and Experimental Immunology, 47(1), 27-33.