Cytolytic T lymphocyte mediated chromium-51 release versus spontaneous release from blast and spleen cell targets at low temperatures

Steven P. Balk, Matthew F. Mescher

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The rate of spontaneous 51Cr release from spleen cell and LPS blast target cells is strongly temperature dependent. Between 32 and 37 °C the rate of spontaneous release increases dramatically with temperature. Cytolytic T-lymphocyte-mediated lysis of these target cells is also temperature dependent, but lysis does not increase greatly above 32 °C. The ratio of specific 51Cr release to spontaneous release can be significantly improved by doing 51Cr-release assays at temperatures below 37 °C.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalCellular Immunology
Volume65
Issue number1
DOIs
StatePublished - Nov 15 1981
Externally publishedYes

Bibliographical note

Funding Information:
by National Institutes of Health Grant CA-14732.

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