Cytokines and immunoglobulin in rheumatic heart disease: Production by blood and tonsillar mononuclear cells

L. C. Miller, E. D. Gray, M. Mansour, Z. H. Abdin, R. Kamel, S. Zaher, W. E. Regelmann

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Rheumatic fever and rheumatic heart disease are considered to result from abnormal immune responses after Group A streptococcal pharyngitis. Production of interleukin 1 (IL-1), tumor necrosis factor-α (TNF), interleukin-2 (IL-2) and immunoglobulin (Ig) by blood and tonsillar mononuclear cells from rheumatic or healthy children was measured after stimulation in vitro by pokeweed mitogen (PWM) or the streptococcal extracellular product, blastogen A (BLA). Tonsillar cells from patients with rheumatic heart disease produced significantly less IL-1, TNF, IL-2, and Ig than control tonsillar cells. In contrast, blood mononuclear cell cultures from rheumatic children produced more TNF and IL-2 than controls. Our findings suggest that abnormal regulation of cytokine and Ig production may contribute to the pathogenesis of acute rheumatic fever and rheumatic heart disease.

Original languageEnglish (US)
Pages (from-to)1436-1442
Number of pages7
JournalJournal of Rheumatology
Volume16
Issue number11
StatePublished - 1989

Keywords

  • Cytokines
  • Rheumatic fever
  • Rheumatic heart disease
  • Tonsil immune function

Fingerprint Dive into the research topics of 'Cytokines and immunoglobulin in rheumatic heart disease: Production by blood and tonsillar mononuclear cells'. Together they form a unique fingerprint.

  • Cite this

    Miller, L. C., Gray, E. D., Mansour, M., Abdin, Z. H., Kamel, R., Zaher, S., & Regelmann, W. E. (1989). Cytokines and immunoglobulin in rheumatic heart disease: Production by blood and tonsillar mononuclear cells. Journal of Rheumatology, 16(11), 1436-1442.