Cytokine-mediated loss of blood dendritic cells during Epstein-Barr virus-associated acute infectious mononucleosis: Implication for immune dysregulation

Archana Panikkar, Corey Smith, Andrew Hislop, Nick Tellam, Vijayendra Dasari, Kristin A. Hogquist, Michelle Wykes, Denis J. Moss, Alan Rickinson, Henry H. Balfour, Rajiv Khanna

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. In the current study we demonstrated a significant loss of circulating myeloid and plasmacytoid dendritic cells (DCs) during acute IM, a loss correlated with the severity of clinical symptoms. In vitro exposure of blood DCs to acute IM plasma resulted in loss of plasmacytoid DCs, and further studies with individual cytokines showed that exposure to interleukin 10 could replicate this effect. Our data provide important mechanistic insight into dysregulated immune homeostasis during acute IM.

Original languageEnglish (US)
Pages (from-to)1957-1961
Number of pages5
JournalJournal of Infectious Diseases
Volume212
Issue number12
DOIs
StatePublished - Jan 1 2015

Keywords

  • Acute infection
  • Antiviral immunity
  • Cytokines
  • Dendritic cells
  • Herpesvirus
  • Immune dysregulation
  • Immune regulation
  • Virus

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