Cytokine expression in the brain has been suggested to mediate various sickness behaviors. Here we report that intraperitoneal injection of a Corynebacterium parvum antigen in C57BL/6 mice was followed by prolonged upregulation of cytokines in the cerebral cortex and subcortical structures in a time course that coincided with reduced spontaneous running activity.
|Original language||English (US)|
|Number of pages||3|
|Journal||Clinical and Diagnostic Laboratory Immunology|
|State||Published - 2001|