Cytokine Circuits in Cardiovascular Disease

Jesse W. Williams, Li hao Huang, Gwendalyn J. Randolph

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Arterial inflammation is a hallmark of atherosclerosis, and appropriate management of this inflammation represents a major unmet therapeutic need for cardiovascular disease patients. Here, we review the diverse contributions of immune cells to atherosclerosis, the mechanisms of immune cell activation in this context, and the cytokine circuits that underlie disease progression. We discuss the recent application of these insights in the form of immunotherapy to treat cardiovascular disease and highlight how studies on the cardiovascular co-morbidity that arises in autoimmunity might reveal additional roles for cytokines in atherosclerosis. Currently, data point to interleukin-1β (IL-1β), tumor necrosis factor (TNF), and IL-17 as cytokines that, at least in some settings, are effective targets to reduce cardiovascular disease progression.

Original languageEnglish (US)
Pages (from-to)941-954
Number of pages14
JournalImmunity
Volume50
Issue number4
DOIs
StatePublished - Apr 16 2019

Bibliographical note

Funding Information:
We gratefully acknowledge Konstantin Zaitsev (Washington University PhD Program in Immunology) for help with generating the Monocle lineage analysis described as unpublished data and Dr. Bernd Zinselmeyer for assistance with illustrations. We are also grateful to Drs. Parrakal Deepak (Washington University) and Jaehoon Choi (Hanyang University) for scientific interactions and recent discussions that have helped to shape parts of this article. The authors are funded by National Institutes of Health (NIH) grants R37 AI049653 and DP1DK109668 to G.J.R. NIH grant K99 HL138163 to J.W.W. and a Career Development Award from the American Heart Association to L.H. G.J.R. is a member of the National Advisory Allergy and Infectious Diseases Council. J.W.W. is presently affiliated with the Department of Integrative Biology and Physiology and the Center for Immunology at the University of Minnesota.

Funding Information:
We gratefully acknowledge Konstantin Zaitsev (Washington University PhD Program in Immunology) for help with generating the Monocle lineage analysis described as unpublished data and Dr. Bernd Zinselmeyer for assistance with illustrations. We are also grateful to Drs. Parrakal Deepak (Washington University) and Jaehoon Choi (Hanyang University) for scientific interactions and recent discussions that have helped to shape parts of this article. The authors are funded by National Institutes of Health (NIH) grants R37 AI049653 and DP1DK109668 to G.J.R., NIH grant K99 HL138163 to J.W.W., and a Career Development Award from the American Heart Association to L.H.

Publisher Copyright:
© 2019 Elsevier Inc.

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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