Cytokine and free radical production by porcine microglia

Shuxian Hu, Chun C. Chao, Kristin V. Khanna, Genya Gekker, Phillip K. Peterson, Thomas W Molitor

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43 Scopus citations

Abstract

Swine have been used increasingly as an animal model for a variety of immunologic purposes. Because the functional activities of porcine microglia, the resident macrophages of the brain, have not been elucidated, highly enriched porcine microglial cell cultures were developed in the present study to assess cytokine and free radical production by these cells compared to microglia of human and murine origin. Porcine microglial cells were found to behave similarly to both human and murine cells in releasing tumor necrosis factor-α and interleukin-1 and in generating superoxide anion. In contrast to murine cells, porcine microglial cells, like human cells, failed to generate NO in response to cytokine stimulation. These findings suggest that swine will serve as an excellent model for investigations of central nervous system diseases in which microglia are involved in host defense or neuronal injury.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalClinical Immunology and Immunopathology
Volume78
Issue number1
DOIs
StatePublished - 1996

Bibliographical note

Funding Information:
This study was supported in part by USPHS Grants DA-04381, DA-09924, DA-08496, AI-35110, and T32-DA-07239.

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