Cystatin c enhances glomerular filtration rate estimating equations in kidney transplant recipients

Aleksandra Kukla, Naim Issa, Scott Jackson, Richard Spong, Meredith C. Foster, Arthur J. Matas, Michael S. Mauer, John H. Eckfeldt, Hassan N. Ibrahim

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: The glomerular filtration rate (GFR) estimating equation incorporating both cystatin C and creatinine perform better than those using creatinine or cystatin C alone in patients with reduced GFR. Whether this equation performs well in kidney transplant recipients cross-sectionally, and more importantly, over time has not been addressed. Methods: We analyzed four GFR estimating equations in participants of the Angiotensin II Blockade for Chronic Allograft Nephropathy Trial (NCT 00067990): Chronic Kidney Disease Epidemiology Collaboration equations based on serum cystatin C and creatinine (eGFR (CKD-EPI-Creat+CysC)), cystatin C alone (eGFR (CKD-EPI-CysC)), creatinine alone (eGFR (CKD-EPI-Creat)) and the Modification of Diet in Renal Disease study equation (eGFR (MDRD)). Iothalamate GFR served as a standard (mGFR). Results: mGFR, serum creatinine, and cystatin C shortly after transplant were 56.1 ± 17.0 ml/min/1.73 m2, 1.2 ± 0.4 mg/dl, and 1.2 ± 0.3 mg/l respectively. eGFR (CKD-EPI-Creat+CysC) was most precise (R2 = 0.50) but slightly more biased than eGFR (MDRD); 9.0 ± 12.7 versus 6.4 ± 15.8 ml/min/1.73 m2, respectively. This improved precision was most evident in recipients with mGFR >60 ml/min/1.73 m2. For relative accuracy, eGFR (MDRD) and eGFR (CKD-EPI-Creat+CysC) had the highest percentage of estimates falling within 30% of mGFR; 75.8 and 68.9%, respectively. Longitudinally, equations incorporating cystatin C most closely paralleled the change in mGFR. Conclusion: eGFR (CKD-EPI-Creat+CysC) is more precise and reflects GFR change over time reasonably well. eGFR (MDRD) had superior performance in recipients with mGFR between 30 and 60 ml/min/1.73 m2.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalAmerican Journal of Nephrology
Volume39
Issue number1
DOIs
StatePublished - Feb 1 2014

Keywords

  • Chronic kidney disease epidemiology collaboration
  • Cystatin C
  • Glomerular filtration rate
  • Kidney transplantation
  • Modification of Diet in Renal Disease

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