CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: No association in the ARIC study

Bharat Thyagarajan, Marcia Brott, Pamela Mink, Aaron R. Folsom, Kristin E. Anderson, William Starr Oetting, Myron Gross

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


We conducted a nested case control study of 178 incident breast cancer cases and 356 controls in the Atherosclerosis Risk in Communities study. We evaluated the association between breast cancer and Val432Leu polymorphism in the CYP1B1 gene and the tetranucleotide repeats in intron 4 of the CYP19 gene. After adjustment for height, age at menopause, age at menarche, BMI, HRT, and alcohol intake, carriers of the Val/Leu or Val/Val genotype had a 1.45 fold (95% CI 0.85-2.47) greater odds of breast cancer than Leu/Leu carriers. There was no association of the breast cancer with any individual CYP19 allele. Compared to individuals homozygous with the 167 allele, odds ratios were close to 1.0 for the 167 heterozygous genotype and for the remaining tetranucleotide repeats combined. Our data shows no association between breast cancer and the Leu432Val polymorphism of the CYP1B1 gene or the tetranucleotide repeats of the CYP19 gene.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalCancer Letters
Issue number2
StatePublished - Apr 2004

Bibliographical note

Funding Information:
The ARIC Study was supported by NHLBI contracts: N01-HC-55015, N01-HC-55016,N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022. This study was supported by NCI Grant R03-CA65473. The authors thank the staff and participants in ARIC for their long-standing contributions. The authors also thank Fan Kong for her assistance with the laboratory procedures for this study.


  • Breast cancer
  • CYP19
  • CYP1B1
  • Estrogen metabolism
  • Prospective study


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