Abstract
A 38-year-old man receiving cyclosporine A after bilateral lung transplantation for cystic fibrosis presented with cortical blindness, generalized seizures, and cerebellar edema. Progressive brainstem compression necessitated emergency posterior fossa decompression. Replacement of cyclosporine A with an alternative immunosuppressive agent, FK506, was followed by rapid neurological recovery and dramatic resolution of radiographic abnormalities. The etiology, clinical features, and radiographic findings of cyclosporine A neurotoxicity are discussed. The pertinent literature is reviewed.
Original language | English (US) |
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Pages (from-to) | 1068-1070 |
Number of pages | 3 |
Journal | Journal of neurosurgery |
Volume | 82 |
Issue number | 6 |
DOIs | |
State | Published - 1995 |
Keywords
- brainstem compression
- cerebellar edema
- cyclosporine A
- drug toxicity
- neurotoxicity