Abstract
Human corneal endothelial cells grown in culture medium were exposed to different concentrations of cyclosporin A in vitro. After 7 days, concentrations of the drug less than 1,000 ng/ml of medium were found nontoxic to the endothelial layer, while greater concentrations killed the cells in 1 hour to 48 hours, depending upon the concentration of the drug. Degenerative cytoplasmic vacuoles were the first sign of toxicity from the drug, leading in higher concentrations to eventual disintegration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 272-277 |
| Number of pages | 6 |
| Journal | Cornea |
| Volume | 3 |
| Issue number | 4 |
| State | Published - Dec 1 1984 |
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