Cyclohexenyl nucleosides: Synthesis of cis-4-(9H-purin-9-yl)-2-cyclohexenylcarbinols

Michael J. Konkel; Robert Vince

doi:10.1016/0040-4020(95)00926-4

Cyclohexenyl nucleosides: Synthesis of cis-4-(9H-purin-9-yl)-2-cyclohexenylcarbinols

Michael J. Konkel, Robert Vince

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

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Abstract

Syntheses of the title compounds were accomplished in 6-7 steps, starting from cyclohexadiene and chlorosulphonyl isocyanate. The key step of the strategy involves a palladium coupling of cyclohexenyl dicarbonate 8 with either 6-chloropurine or 2-amino-6-chloropurine.

Original language	English (US)
Pages (from-to)	799-808
Number of pages	10
Journal	Tetrahedron
Volume	52
Issue number	3
DOIs	https://doi.org/10.1016/0040-4020(95)00926-4
State	Published - Jan 15 1996

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title = "Cyclohexenyl nucleosides: Synthesis of cis-4-(9H-purin-9-yl)-2-cyclohexenylcarbinols",

abstract = "Syntheses of the title compounds were accomplished in 6-7 steps, starting from cyclohexadiene and chlorosulphonyl isocyanate. The key step of the strategy involves a palladium coupling of cyclohexenyl dicarbonate 8 with either 6-chloropurine or 2-amino-6-chloropurine.",

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T1 - Cyclohexenyl nucleosides

T2 - Synthesis of cis-4-(9H-purin-9-yl)-2-cyclohexenylcarbinols

AU - Konkel, Michael J.

AU - Vince, Robert

PY - 1996/1/15

Y1 - 1996/1/15

N2 - Syntheses of the title compounds were accomplished in 6-7 steps, starting from cyclohexadiene and chlorosulphonyl isocyanate. The key step of the strategy involves a palladium coupling of cyclohexenyl dicarbonate 8 with either 6-chloropurine or 2-amino-6-chloropurine.

AB - Syntheses of the title compounds were accomplished in 6-7 steps, starting from cyclohexadiene and chlorosulphonyl isocyanate. The key step of the strategy involves a palladium coupling of cyclohexenyl dicarbonate 8 with either 6-chloropurine or 2-amino-6-chloropurine.

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DO - 10.1016/0040-4020(95)00926-4

M3 - Article

AN - SCOPUS:0030021563

SN - 0040-4020

VL - 52

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JO - Tetrahedron

JF - Tetrahedron

IS - 3

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Cyclohexenyl nucleosides: Synthesis of cis-4-(9H-purin-9-yl)-2-cyclohexenylcarbinols

Abstract

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