Cyclic leukocytosis in chronic myelogenous leukemia: new perspectives on pathogenesis and therapy

R. A. Gatti, W. A. Robinson, A. S. Deinard, M. Nesbit, J. J. McCullough, M. Ballow, R. A. Good

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Abstract

Studies were performed on a teen age female identical twin with cyclic leukocytosis and Ph 1 positive chronic myelogenous leukemia (CML), in an attempt to analyze the relationship of these cycles and to utilize the cycles as reference points for kinetic studies and as landmarks in the progression of her disease. She remained untreated for 2.5 yr. Colony stimulating factor levels showed an inverse relationship to the peripheral leukocyte count. Two distinct phases in cyclic patterns of peripheral leukocyte counts prior to treatment could be appreciated in retrospect: phase 1, a stable 15 mth period during which leukocyte counts peaked every 10 wk and then returned to baseline levels, and phase 2, an 18 mth period of insidious deterioration during which the low points of successive cycles became progressively higher and leukocytes were accumulating in the peripheral blood at a rate of 400 X 10 6/day. The authors propose that the increased marrow production of myeloid cells in this disease does not represent a life threatening situation until cell accumulation begins. They attempted, therefore, to halt or to reverse this accumulation by cell separator leukapheresis.

Original languageEnglish (US)
Pages (from-to)771-782
Number of pages12
JournalBlood
Volume41
Issue number6
StatePublished - Dec 1 1973

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Leukocytosis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukocyte Count
Colony-Stimulating Factors
Separators
Leukapheresis
Deterioration
Blood
Monozygotic Twins
Myeloid Cells
Kinetics
Disease Progression
Leukocytes
Therapeutics
Bone Marrow

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Gatti, R. A., Robinson, W. A., Deinard, A. S., Nesbit, M., McCullough, J. J., Ballow, M., & Good, R. A. (1973). Cyclic leukocytosis in chronic myelogenous leukemia: new perspectives on pathogenesis and therapy. Blood, 41(6), 771-782.

Cyclic leukocytosis in chronic myelogenous leukemia : new perspectives on pathogenesis and therapy. / Gatti, R. A.; Robinson, W. A.; Deinard, A. S.; Nesbit, M.; McCullough, J. J.; Ballow, M.; Good, R. A.

In: Blood, Vol. 41, No. 6, 01.12.1973, p. 771-782.

Research output: Contribution to journalArticle

Gatti, RA, Robinson, WA, Deinard, AS, Nesbit, M, McCullough, JJ, Ballow, M & Good, RA 1973, 'Cyclic leukocytosis in chronic myelogenous leukemia: new perspectives on pathogenesis and therapy' Blood, vol. 41, no. 6, pp. 771-782.
Gatti RA, Robinson WA, Deinard AS, Nesbit M, McCullough JJ, Ballow M et al. Cyclic leukocytosis in chronic myelogenous leukemia: new perspectives on pathogenesis and therapy. Blood. 1973 Dec 1;41(6):771-782.
Gatti, R. A. ; Robinson, W. A. ; Deinard, A. S. ; Nesbit, M. ; McCullough, J. J. ; Ballow, M. ; Good, R. A. / Cyclic leukocytosis in chronic myelogenous leukemia : new perspectives on pathogenesis and therapy. In: Blood. 1973 ; Vol. 41, No. 6. pp. 771-782.
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