Cyclic AMP oscillations in suspensions of Dictyostelium discoideum.

P. B. Monk, H. G. Othmer

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A model developed previously for signal relay and adaptation in the cellular slime mould Dictyostelium discoideum is shown to account for the observed oscillations of calcium and cyclic AMP in cellular suspensions. A qualitative argument is given which explains how the oscillations arise, and numerical computations show how characteristics such as the period and amplitude of the periodic solutions depend on parameters in the model. Several extensions of the basic model are investigated, including the effect of cell aggregation and the effect of time delays in the activation and adaptation processes. The dynamics of mixed cell populations in which only a small fraction of the cells are capable of autonomous oscillation are also studied.

Original languageEnglish (US)
Pages (from-to)185-224
Number of pages40
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume323
Issue number1215
DOIs
StatePublished - Mar 15 1989

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