Cyanide antidotes for mass casualties: Water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration

Steven E. Patterson, Alexandre R. Monteil, Jonathan F. Cohen, Daune L. Crankshaw, Robert Vince, Herbert T. Nagasawa

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.

Original languageEnglish (US)
Pages (from-to)1346-1349
Number of pages4
JournalJournal of medicinal chemistry
Volume56
Issue number3
DOIs
StatePublished - Feb 14 2013

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