Cutting the Gordian knot: Untangling gasdermin C from pyroptosis

Zhaoyu Lin; Hai Bin Ruan

doi:10.1016/j.immuni.2025.09.015

Cutting the Gordian knot: Untangling gasdermin C from pyroptosis

Zhaoyu Lin
, Hai Bin Ruan

Physiology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Membrane targeting and pore formation of gasdermin C are facilitated by its proteolytic cleavage. In this issue of Immunity, Pandey et al. show how cathepsin S cleaves intestinal epithelial gasdermin C to amplify type 2 immune responses.

Original language	English (US)
Pages (from-to)	2359-2361
Number of pages	3
Journal	Immunity
Volume	58
Issue number	10
DOIs	https://doi.org/10.1016/j.immuni.2025.09.015
State	Published - Oct 14 2025

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© 2025 Elsevier Inc.

PubMed: MeSH publication types

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10.1016/j.immuni.2025.09.015

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title = "Cutting the Gordian knot: Untangling gasdermin C from pyroptosis",

abstract = "Membrane targeting and pore formation of gasdermin C are facilitated by its proteolytic cleavage. In this issue of Immunity, Pandey et al. show how cathepsin S cleaves intestinal epithelial gasdermin C to amplify type 2 immune responses.",

author = "Zhaoyu Lin and Ruan, \{Hai Bin\}",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

month = oct,

day = "14",

doi = "10.1016/j.immuni.2025.09.015",

language = "English (US)",

volume = "58",

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T1 - Cutting the Gordian knot

T2 - Untangling gasdermin C from pyroptosis

AU - Lin, Zhaoyu

AU - Ruan, Hai Bin

PY - 2025/10/14

Y1 - 2025/10/14

N2 - Membrane targeting and pore formation of gasdermin C are facilitated by its proteolytic cleavage. In this issue of Immunity, Pandey et al. show how cathepsin S cleaves intestinal epithelial gasdermin C to amplify type 2 immune responses.

AB - Membrane targeting and pore formation of gasdermin C are facilitated by its proteolytic cleavage. In this issue of Immunity, Pandey et al. show how cathepsin S cleaves intestinal epithelial gasdermin C to amplify type 2 immune responses.

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UR - https://www.scopus.com/pages/publications/105017879611#tab=citedBy

U2 - 10.1016/j.immuni.2025.09.015

DO - 10.1016/j.immuni.2025.09.015

M3 - Comment/debate

C2 - 41092892

AN - SCOPUS:105017879611

SN - 1074-7613

VL - 58

SP - 2359

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JO - Immunity

JF - Immunity

IS - 10

ER -

Cutting the Gordian knot: Untangling gasdermin C from pyroptosis

Abstract

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