Cutting edge: Transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15Rα by the same cells

Michelle M. Sandau, Kimberly S. Schluns, Leo Lefrancois, Stephen C. Jameson

Research output: Contribution to journalArticle

139 Scopus citations

Abstract

IL-15 is critical for generation of multiple lymphoid subsets. Recent data have demonstrated a unique aspect of responses to IL-15, in that cells bearing the IL-15Rα chain can bind soluble IL-15 and "transpresent" the cytokine to other cells, allowing the latter to respond to IL-15. However, it is unclear whether IL-15 is normally secreted and then becomes bound to surface IL-15Rα on bystander cells, or whether transpresentation is mediated by the same cells which synthesize IL-15. Using mixed bone marrow chimeric mice, we present evidence for the latter model, showing that development of NK cells and memory phenotype CD8 T cells necessitates that both IL-15 and IL-15Rα be expressed by the same population of cells. These data argue that soluble forms of IL-15 are irrelevant for physiological responses to this cytokine, and the implications of this finding are discussed.

Original languageEnglish (US)
Pages (from-to)6537-6541
Number of pages5
JournalJournal of Immunology
Volume173
Issue number11
DOIs
StatePublished - Dec 1 2004

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