Cutting edge: NKG2ChiCD57+ NK cells respond specifically to acute infection with cytomegalovirus and not epstein-barr virus

Deborah W. Hendricks, Henry H. Balfour, Samantha K. Dunmire, David O. Schmeling, Kristin A. Hogquist, Lewis L. Lanier

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

CMV induces the expansion of a unique subset of human NK cells expressing high levels of the activating CD94-NKG2C receptor that persist after control of the infection. We investigated whether this subset is CMV specific or is also responsive to acute infection with EBV. We describe a longitudinal study of CMV2 and CMV+ students who were acutely infected with EBV. The NKG2Chi NK subset was not expanded by EBV infection. However, EBV infection caused a decrease in the absolute number of immature CD56bright CD162 NK cells in the blood and, in CMV+ individuals, induced an increased frequency of mature CD56dim NKG2A+CD57+ NK cells in the blood that persisted into latency. These results provide further evidence that NKG2C+ NK cells are CMV specific and suggest that EBV infection alters the repertoire of NK cells in the blood.

Original languageEnglish (US)
Pages (from-to)4492-4496
Number of pages5
JournalJournal of Immunology
Volume192
Issue number10
DOIs
StatePublished - May 15 2014

Fingerprint Dive into the research topics of 'Cutting edge: NKG2C<sup>hi</sup>CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not epstein-barr virus'. Together they form a unique fingerprint.

  • Cite this