Cutting edge: Gut microenvironment promotes differentiation of a unique memory CD8 T cell population

David Masopust, Vaiva Vezys, E. John Wherry, Daniel L. Barber, Rafi Ahmed

Research output: Contribution to journalArticle

236 Scopus citations

Abstract

Whether tissue microenvironment influences memory CD8 T cell differentiation is unclear. We demonstrate that virus-specific intraepithelial lymphocytes in gut resemble neither central nor effector memory CD8 T cells isolated from spleen or blood. This unique phenotype arises in situ within the gut, suggesting that anatomic location plays an inductive role in the memory differentiation program. In support of this hypothesis, memory CD8 T cells changed phenotype upon change in location. After transfer and in vivo restimulation, gut or spleen memory cells proliferated, disseminated into spleen and gut, and adopted the memory T cell phenotype characteristic of their new environment. Our data suggests that anatomic location directly impacts the memory T cell differentiation program.

Original languageEnglish (US)
Pages (from-to)2079-2083
Number of pages5
JournalJournal of Immunology
Volume176
Issue number4
DOIs
StatePublished - Feb 15 2006

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