Cutaneous Delayed-Type Hypersensitivity to Surfactants

Joseph F. Fowler, Cristin N. Shaughnessy, Donald V. Belsito, Joel G. Dekoven, Vincent A. Deleo, Anthony F. Fransway, Howard I. Maibach, James G. Marks, C. G Toby Mathias, Melanie Pratt, Denis Sasseville, James S. Taylor, Erin M. Warshaw, Matthew J. Zirwas, Kathryn A. Zug, Douglas Lorenz

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background Repeated and prolonged use of surfactants can cause irritant as well as allergic contact dermatitis. Objective This study reports the frequency of positive patch test results to surfactants tested on the North American Contact Dermatitis Group screening series including cocamidopropyl betaine (CAPB), amidoamine (AA), dimethylaminopropylamine (DMAPA), oleamidopropyl dimethylamine (OPD), and cocamide diethanolamide (CDEA), and correlations of positive reactions between CAPB and the other surfactants. Methods This was a retrospective analysis of 10 877 patients patch tested between 2009 and 2014 to the surfactants CAPB, AA, DMAPA, OPD, and CDEA. Frequencies of positive reactions to these surfactants were calculated, and trends of reactivity between the surfactants analyzed. Conclusions The OPD had the highest rate of positive patch reactions (2.3%) followed by DMAPA (1.7%), and CAPB (1.4%). The AA and CDEA had the lowest rate of positive reactions (0.8%). There was a high degree of overlap in positive patch tests between the surfactants. The CDEA was the least likely to coreact with another surfactant.

Original languageEnglish (US)
Pages (from-to)268-270
Number of pages3
Issue number6
StatePublished - Nov 1 2015

Bibliographical note

Publisher Copyright:
© 2015 American Contact Dermatitis Society.


Dive into the research topics of 'Cutaneous Delayed-Type Hypersensitivity to Surfactants'. Together they form a unique fingerprint.

Cite this