Cutaneous Delayed-Type Hypersensitivity to Surfactants

Joseph F. Fowler, Cristin N. Shaughnessy, Donald V. Belsito, Joel G. Dekoven, Vincent A. Deleo, Anthony F. Fransway, Howard I. Maibach, James G. Marks, C. G Toby Mathias, Melanie Pratt, Denis Sasseville, James S. Taylor, Erin M. Warshaw, Matthew J. Zirwas, Kathryn A. Zug, Douglas Lorenz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Repeated and prolonged use of surfactants can cause irritant as well as allergic contact dermatitis. Objective This study reports the frequency of positive patch test results to surfactants tested on the North American Contact Dermatitis Group screening series including cocamidopropyl betaine (CAPB), amidoamine (AA), dimethylaminopropylamine (DMAPA), oleamidopropyl dimethylamine (OPD), and cocamide diethanolamide (CDEA), and correlations of positive reactions between CAPB and the other surfactants. Methods This was a retrospective analysis of 10 877 patients patch tested between 2009 and 2014 to the surfactants CAPB, AA, DMAPA, OPD, and CDEA. Frequencies of positive reactions to these surfactants were calculated, and trends of reactivity between the surfactants analyzed. Conclusions The OPD had the highest rate of positive patch reactions (2.3%) followed by DMAPA (1.7%), and CAPB (1.4%). The AA and CDEA had the lowest rate of positive reactions (0.8%). There was a high degree of overlap in positive patch tests between the surfactants. The CDEA was the least likely to coreact with another surfactant.

Original languageEnglish (US)
Pages (from-to)268-270
Number of pages3
JournalDermatitis
Volume26
Issue number6
DOIs
StatePublished - Jan 1 2015

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Delayed Hypersensitivity
Surface-Active Agents
Skin
Patch Tests
Allergic Contact Dermatitis
Irritants
Contact Dermatitis
cocamidopropyl betaine

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Fowler, J. F., Shaughnessy, C. N., Belsito, D. V., Dekoven, J. G., Deleo, V. A., Fransway, A. F., ... Lorenz, D. (2015). Cutaneous Delayed-Type Hypersensitivity to Surfactants. Dermatitis, 26(6), 268-270. https://doi.org/10.1097/DER.0000000000000150

Cutaneous Delayed-Type Hypersensitivity to Surfactants. / Fowler, Joseph F.; Shaughnessy, Cristin N.; Belsito, Donald V.; Dekoven, Joel G.; Deleo, Vincent A.; Fransway, Anthony F.; Maibach, Howard I.; Marks, James G.; Mathias, C. G Toby; Pratt, Melanie; Sasseville, Denis; Taylor, James S.; Warshaw, Erin M.; Zirwas, Matthew J.; Zug, Kathryn A.; Lorenz, Douglas.

In: Dermatitis, Vol. 26, No. 6, 01.01.2015, p. 268-270.

Research output: Contribution to journalArticle

Fowler, JF, Shaughnessy, CN, Belsito, DV, Dekoven, JG, Deleo, VA, Fransway, AF, Maibach, HI, Marks, JG, Mathias, CGT, Pratt, M, Sasseville, D, Taylor, JS, Warshaw, EM, Zirwas, MJ, Zug, KA & Lorenz, D 2015, 'Cutaneous Delayed-Type Hypersensitivity to Surfactants', Dermatitis, vol. 26, no. 6, pp. 268-270. https://doi.org/10.1097/DER.0000000000000150
Fowler JF, Shaughnessy CN, Belsito DV, Dekoven JG, Deleo VA, Fransway AF et al. Cutaneous Delayed-Type Hypersensitivity to Surfactants. Dermatitis. 2015 Jan 1;26(6):268-270. https://doi.org/10.1097/DER.0000000000000150
Fowler, Joseph F. ; Shaughnessy, Cristin N. ; Belsito, Donald V. ; Dekoven, Joel G. ; Deleo, Vincent A. ; Fransway, Anthony F. ; Maibach, Howard I. ; Marks, James G. ; Mathias, C. G Toby ; Pratt, Melanie ; Sasseville, Denis ; Taylor, James S. ; Warshaw, Erin M. ; Zirwas, Matthew J. ; Zug, Kathryn A. ; Lorenz, Douglas. / Cutaneous Delayed-Type Hypersensitivity to Surfactants. In: Dermatitis. 2015 ; Vol. 26, No. 6. pp. 268-270.
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abstract = "Background Repeated and prolonged use of surfactants can cause irritant as well as allergic contact dermatitis. Objective This study reports the frequency of positive patch test results to surfactants tested on the North American Contact Dermatitis Group screening series including cocamidopropyl betaine (CAPB), amidoamine (AA), dimethylaminopropylamine (DMAPA), oleamidopropyl dimethylamine (OPD), and cocamide diethanolamide (CDEA), and correlations of positive reactions between CAPB and the other surfactants. Methods This was a retrospective analysis of 10 877 patients patch tested between 2009 and 2014 to the surfactants CAPB, AA, DMAPA, OPD, and CDEA. Frequencies of positive reactions to these surfactants were calculated, and trends of reactivity between the surfactants analyzed. Conclusions The OPD had the highest rate of positive patch reactions (2.3{\%}) followed by DMAPA (1.7{\%}), and CAPB (1.4{\%}). The AA and CDEA had the lowest rate of positive reactions (0.8{\%}). There was a high degree of overlap in positive patch tests between the surfactants. The CDEA was the least likely to coreact with another surfactant.",
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AU - Deleo, Vincent A.

AU - Fransway, Anthony F.

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N2 - Background Repeated and prolonged use of surfactants can cause irritant as well as allergic contact dermatitis. Objective This study reports the frequency of positive patch test results to surfactants tested on the North American Contact Dermatitis Group screening series including cocamidopropyl betaine (CAPB), amidoamine (AA), dimethylaminopropylamine (DMAPA), oleamidopropyl dimethylamine (OPD), and cocamide diethanolamide (CDEA), and correlations of positive reactions between CAPB and the other surfactants. Methods This was a retrospective analysis of 10 877 patients patch tested between 2009 and 2014 to the surfactants CAPB, AA, DMAPA, OPD, and CDEA. Frequencies of positive reactions to these surfactants were calculated, and trends of reactivity between the surfactants analyzed. Conclusions The OPD had the highest rate of positive patch reactions (2.3%) followed by DMAPA (1.7%), and CAPB (1.4%). The AA and CDEA had the lowest rate of positive reactions (0.8%). There was a high degree of overlap in positive patch tests between the surfactants. The CDEA was the least likely to coreact with another surfactant.

AB - Background Repeated and prolonged use of surfactants can cause irritant as well as allergic contact dermatitis. Objective This study reports the frequency of positive patch test results to surfactants tested on the North American Contact Dermatitis Group screening series including cocamidopropyl betaine (CAPB), amidoamine (AA), dimethylaminopropylamine (DMAPA), oleamidopropyl dimethylamine (OPD), and cocamide diethanolamide (CDEA), and correlations of positive reactions between CAPB and the other surfactants. Methods This was a retrospective analysis of 10 877 patients patch tested between 2009 and 2014 to the surfactants CAPB, AA, DMAPA, OPD, and CDEA. Frequencies of positive reactions to these surfactants were calculated, and trends of reactivity between the surfactants analyzed. Conclusions The OPD had the highest rate of positive patch reactions (2.3%) followed by DMAPA (1.7%), and CAPB (1.4%). The AA and CDEA had the lowest rate of positive reactions (0.8%). There was a high degree of overlap in positive patch tests between the surfactants. The CDEA was the least likely to coreact with another surfactant.

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