Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

Alifiya S. Motiwala; Lingling Li; Vivek Kapur; Srinand Sreevatsan

doi:10.1016/j.micinf.2005.12.003

Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

Alifiya S. Motiwala, Lingling Li, Vivek Kapur, Srinand Sreevatsan

Veterinary Population Medicine

Research output: Contribution to journal › Short survey › peer-review

62 Scopus citations

Abstract

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.

Original language	English (US)
Pages (from-to)	1406-1418
Number of pages	13
Journal	Microbes and Infection
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/j.micinf.2005.12.003
State	Published - Apr 2006

Bibliographical note

Funding Information:
This work was supported by state and federal funds appropriated to the Ohio Agricultural Research and Development Center (OARDC). Research in SS laboratory is supported through OARDC Competitive Research Enhancement Grants and the Johne's disease integrated program grant (USDA-NRICAP).

Keywords

Amplified fragment length polymorphism
Crohn's disease
Diversity
Genotyping
Johne's disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2005.12.003

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title = "Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis",

abstract = "Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.",

keywords = "Amplified fragment length polymorphism, Crohn's disease, Diversity, Genotyping, Johne's disease",

author = "Motiwala, {Alifiya S.} and Lingling Li and Vivek Kapur and Srinand Sreevatsan",

note = "Funding Information: This work was supported by state and federal funds appropriated to the Ohio Agricultural Research and Development Center (OARDC). Research in SS laboratory is supported through OARDC Competitive Research Enhancement Grants and the Johne's disease integrated program grant (USDA-NRICAP).",

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T1 - Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

AU - Motiwala, Alifiya S.

AU - Li, Lingling

AU - Kapur, Vivek

AU - Sreevatsan, Srinand

N1 - Funding Information: This work was supported by state and federal funds appropriated to the Ohio Agricultural Research and Development Center (OARDC). Research in SS laboratory is supported through OARDC Competitive Research Enhancement Grants and the Johne's disease integrated program grant (USDA-NRICAP).

PY - 2006/4

Y1 - 2006/4

N2 - Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.

AB - Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.

KW - Amplified fragment length polymorphism

KW - Crohn's disease

KW - Diversity

KW - Genotyping

KW - Johne's disease

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U2 - 10.1016/j.micinf.2005.12.003

DO - 10.1016/j.micinf.2005.12.003

M3 - Short survey

C2 - 16697677

AN - SCOPUS:33744820285

SN - 1286-4579

VL - 8

SP - 1406

EP - 1418

JO - Microbes and Infection

JF - Microbes and Infection

IS - 5

ER -

Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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