Current state of in vivo preclinical heart valve evaluation

Christopher T. Salerno, Jeffrianne Droel, Richard W Bianco

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The use of animals to predict prosthetic valve performance in humans has now been in operation for over 25 years. Studies have focused on improvements in structural integrity, anti-thrombogenicity and anticalcification, and provide extensive in vivo analysis and validation of a valve before its clinical evaluation. Many animal models have been developed for such investigations, including calves, goats, pigs, baboons, dogs and adult sheep. Recent models used to assess prosthetic mitral valves have involved site- specific testing in several species; the present study represents the largest series of orthotopically implanted stentless bioprosthetic aortic valves and the first to utilize a juvenile sheep model for the aortic position.

Original languageEnglish (US)
Pages (from-to)158-162
Number of pages5
JournalJournal of Heart Valve Disease
Issue number2
StatePublished - Mar 1998


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