Current Concepts Regarding the Effect of Wound Microbial Ecology and Biofilms on Wound Healing

Carrie E. Black, J. William Costerton

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

Biofilms are a collection of microbes that adhere to surfaces by manufacturing a matrix that shields them from environmental elements. Wound biofilms are difficult to evaluate clinically, and standard culture methods are inadequate for capturing the true bioburden present in the biofilm. New molecular techniques provide the means for rapid detection and evaluation of wound biofilms, and may prove to be useful in the clinical setting. Studies have shown that many commercial topical agents and wound dressings in use are ineffective against the biofilm matrix. At this stage, mechanical debridement appears to be essential in the eradication of a wound biofilm. Topical antimicrobial agents and antibiotics may be effective in the treatment of the wound bed after debridement in the prevention of biofilm reformation.

Original languageEnglish (US)
Pages (from-to)1147-1160
Number of pages14
JournalSurgical Clinics of North America
Volume90
Issue number6
DOIs
StatePublished - Dec 2010

Bibliographical note

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Biofilm
  • Chronic wound
  • Microbial ecology
  • Microbiology
  • Molecular diagnostics

Fingerprint Dive into the research topics of 'Current Concepts Regarding the Effect of Wound Microbial Ecology and Biofilms on Wound Healing'. Together they form a unique fingerprint.

Cite this