CSPG4 gene expression in nasopharyngeal carcinoma and control tissues

Yali Song, Xiaoling Li, Lili Huang, Qiao Li, Mengxi Sun, Wenling Zhang, Lei Shi, Songqing Fan, Zhaojian Gong, Zhengyuan Yu, Bo Xiang, Shuping Peng, Wei Xiong, Jianbo Yang, Zhaoyang Zeng, Gui Yuan Li

Research output: Contribution to journalArticlepeer-review


Objective: To study the expression of chondroitin sulfate proteoglycan 4 (CSPG4) gene in nasopharyngeal carcinoma (NPC) and control tissues. Methods: The CSPG4 mRNA expression of gene in 4 cases with normal nasopharyngeal epithelial tissue and 18 cases with NPC, including 6 stage- II, 5 stage-III, and 7 stage-IV cases, was determined by real-time quantitative PCR. A tissue microarray containing 92 cases of control and 187 cases of NPC tissues was constructed, and the CSPG4 protein expression level was assayed by immunohistochemistry. Results: CSPG4 mRNA was barely expressed in the normal tissues of nasopharyngeal epithelium, but significantly upregulated in the NPC biopsies (P=0.017) and positively correlated with the NPC clinical stage. The CSPG4 protein expression was also higher in NPC than in the controls. CSPG4 was significantly expressed in 91.98% of NPC cases, whereas the percentage of high CSPG4 expression cases was 76.09% in the control group (P=0.001). Conclusion: The CSPG4 gene is upregulated in NPC biopsies and is directly associated with NPC clinical staging, implying the probable involvement of CSPG4 in the development of NPC. The detailed mechanism of CSPG4 in carcinogenesis and its potential clinical application in NPC should be investigated further.

Original languageEnglish (US)
Pages (from-to)1997-2000
Number of pages4
JournalChinese Journal of Clinical Oncology
Issue number24
StatePublished - Dec 30 2012

Bibliographical note

Funding Information:
We acknowledge the work of the NARMS retail meat surveillance sites in the isolation and characterization of retail meat isolates. We specifically recognize the efforts of microbiology and epidemiology staff at the Georgia Department of Public Health and the South Carolina Department of Public Health and Environmental Control who participated in the study, but were unable to coauthor this article. We also acknowledge the following individuals: Melissa Glenn, Brent Volker, Ron Miller, Ruby Singh, and Amber McCoig for their comments and suggestions. The views expressed in this article are those of the authors and do not necessarily reflect the official policy of the Department of Health and Human Services, the U.S. Food and Drug Administration, or the U.S. Government. Reference to any commercial materials, equipment, or process does not in any way constitute approval, endorsement, or recommendation by the Food and Drug Administration. Supplemental material associated with this article can be found online at: https://doi.org/10.4315/JFP-21-005.s1


  • CSPG4 gene
  • Expression
  • Nasopharyngeal carcinoma
  • Tissue microarray


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