CSF findings in adrenoleukodystrophy: Correlation between measures of cytokines, IgG production, and disease severity

John P. Phillips, Lawrence A. Lockman, Elsa G Shapiro, Bruce R Blazar, Daniel J. Loes, Hugo W. Moser, William Krivit

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The childhood-onset cerebral form of adrenoleukodystrophy has a devastating neurologic prognosis. Unfortunately, there is no early method of distinguishing it from the more benign forms of adrenoleukodystrophy, such as adrenomyeloneuropathy. To evaluate the manner in which this disease entity may be reflected in the cerebrospinal fluid, we studied a consecutive series of 19 patients, all with biochemically proved adrenoleu-kodystrophy. Total protein, immunoglobulin production, cytokine levels, and cerebrospinal fluid pressure were measured. In this single sample of cerebrospinal fluid, a significant correlation existed between clinical stage of the illness and cerebrospinal fluid myelin basic protein. No correlation existed with total protein, cytokines, or measures of immunoglobulin production.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalPediatric Neurology
Volume10
Issue number4
DOIs
StatePublished - Jun 1994

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