Crystal structure and thermal behavior of nedocromil nickel octahydrate

Haijian Zhu, Victor G. Young, David J.W. Grant

Research output: Contribution to journalArticle

6 Scopus citations


The hydration behavior of a salt depends on the nature of the cation and the anion and on the molecular packing. A transition metal salt (nickel) of nedocromil was prepared and its crystal structure was elucidated in an attempt to study the influence of the nature of the bivalent cation on the structure, water interactions and molecular packing. Crystal data: nedocromil nickel octahydrate (NNi), orthorhombic, Pca21, a = 29.5446(1) Å, b = 25.0444(1) Å, c = 13.3767(2) Å, Z = 16. The Ni2+, has octahedral coordination, but the coordination environments of the cations and the bonding environments of the water molecules differ. NNi contains four Ni2+ ions in the asymmetric unit, two of which are each octahedrally coordinated to five water molecules and to a carboxyl oxygen. The two remaining Ni2+ ions are linked in a Ni2(H2O)10+4 species. Thermal analytical data for NNi show that the water molecules in this hydrate are lost in a single step dehydration, which may be attributed to the fairly continuous water layer in the ac plane of the crystal lattice.

Original languageEnglish (US)
Pages (from-to)23-33
Number of pages11
JournalInternational journal of pharmaceutics
Issue number1-2
StatePublished - Jan 31 2002


  • Crystal structure
  • Dehydration
  • Hydrate
  • Nedocromil
  • Powder X-ray diffraction, Single crystal X-ray
  • Thermal analysis

Fingerprint Dive into the research topics of 'Crystal structure and thermal behavior of nedocromil nickel octahydrate'. Together they form a unique fingerprint.

Cite this