Crystal forms of a lysine-49 phospholipase A2 from the eastern cottonmouth snake

Laura L. Clancy, Timothy J. Rydel, Steven W. Muchmore, Debra R. Holland, Keith D. Watenpaugh, Barry C. Finzel, Howard M. Einspahr

Research output: Contribution to journalLetterpeer-review


As part of an effort to determine the structure of a lysine-49 variant phospholipase A2 from the venom of a North American pit viper, the eastern cottonmouth (Agkistrodon piscivorus piscivorus), we have produced five different crystal forms grown under a variety of crystallization conditions. They include an orthorthombic form (P212121 or P21212; a=87.8(3) Å, b=76.2(3) Å,c=57.4(4) Å), an hexagonal form (space group P6122 or its enantiomer; a=b=62.22(3) Å, c=137.1(3) Å) and two tetragonal forms - a neutral pH form (space group P41212 or its enantiomer; a = b = 81.99(3) Å) and high pH form (space group P41212; a = b = 71.5(1) Å, c = 57.6(2) Å one molecule per asymmetric unit) - the latter of which was used for structure determination.

Original languageEnglish (US)
Pages (from-to)868-870
Number of pages3
JournalJournal of Crystal Growth
Issue number4
StatePublished - Sep 1990

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