Cryptosporidium: host and parasite transcriptome in infection

Rachel M.Bone Relat, Roberta M. O'Connor

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Cryptosporidium is a waterborne gastrointestinal parasite that causes outbreaks of diarrheal disease worldwide. Despite the impact of this parasite on human health there are no effective drugs or vaccines. Transcriptomic data can provide insights into host-parasite interactions that lead to identification of targets for therapeutic interventions. However, for Cryptosporidium, interpreting transcriptomes has been challenging, in part due to the presence of multiple life cycle stages, the lack of appropriate host cells and the inability to culture the parasite through its complete life cycle. The recent improvements in cell culture and the ability to tag and isolate specific life cycle stages will radically improve transcriptomic data and advance our understanding of Cryptosporidium host-parasite interactions.

Original languageEnglish (US)
Pages (from-to)138-145
Number of pages8
JournalCurrent Opinion in Microbiology
Volume58
DOIs
StatePublished - Dec 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

PubMed: MeSH publication types

  • Journal Article
  • Review

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