Cryptosporidiosis in HIV/AIDS patients in Kenya: Clinical features, epidemiology, molecular characterization and antibody responses

Jane W. Wanyiri, Henry Kanyi, Samuel Maina, David E. Wang, Aaron Steen, Paul Ngugi, Timothy Kamau, Tabitha Waithera, Roberta O'Connor, Kimani Gachuhi, Claire N. Wamae, Mkaya Mwamburi, Honorine D. Ward

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We investigated the epidemiological and clinical features of cryptosporidiosis, the molecular characteristics of infecting species and serum antibody responses to three Cryptosporidium-specific antigens in human immunodeficiency virus (HIV) /acquired immunodeficiency syndrome (AIDS) patients in Kenya. Cryptosporidium was the most prevalent enteric pathogen and was identified in 56 of 164 (34%) of HIV/AIDS patients, including 25 of 70 (36%) with diarrhea and 31 of 94 (33%) without diarrhea. Diarrhea in patients exclusively infected with Cryptosporidium was significantly associated with the number of children per household, contact with animals, and water treatment. Cryptosporidium hominis was the most prevalent species and the most prevalent subtype family was Ib. Patients without diarrhea had significantly higher serum IgG levels to Chgp15, Chgp40 and Cp23, and higher fecal IgA levels to Chgp15 and Chgp40 than those with diarrhea suggesting that antibody responses to these antigens may be associated with protection from diarrhea and supporting further investigation of these antigens as vaccine candidates.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume91
Issue number2
DOIs
StatePublished - Aug 2014
Externally publishedYes

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