Cryptococcal meningitis with false-positive cytology in the CSF. Use of T-cell rosetting to exclude meningeal lymphoma

Scott F Davies; B. J. Gormus; R. Yarchoan; M. E. Kaplan

doi:10.1001/jama.239.22.2369

Cryptococcal meningitis with false-positive cytology in the CSF. Use of T-cell rosetting to exclude meningeal lymphoma

Scott F Davies, B. J. Gormus, R. Yarchoan, M. E. Kaplan

Pulmonary, Allergy, Critical Care and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Cryptococcal meningitis is a frequently described complication of malignant lymphoma. A patient with nodular, poorly differentiated lymphocytic lymphoma (a B-cell neoplasm) had a notable alteration in mental status. Examination of the CSF showed characteristic cryptococcal organisms, but also was believed to demonstrate CNS involvement with lymphoma. A T-cell rosetting assay proved clinically useful by identifying the atypical lymphocytes as T cells rather than neoplastic B cells.

Original language	English (US)
Pages (from-to)	2369-2370
Number of pages	2
Journal	Journal of the American Medical Association
Volume	239
Issue number	22
DOIs	https://doi.org/10.1001/jama.239.22.2369
State	Published - Dec 1 1978

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abstract = "Cryptococcal meningitis is a frequently described complication of malignant lymphoma. A patient with nodular, poorly differentiated lymphocytic lymphoma (a B-cell neoplasm) had a notable alteration in mental status. Examination of the CSF showed characteristic cryptococcal organisms, but also was believed to demonstrate CNS involvement with lymphoma. A T-cell rosetting assay proved clinically useful by identifying the atypical lymphocytes as T cells rather than neoplastic B cells.",

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AU - Kaplan, M. E.

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N2 - Cryptococcal meningitis is a frequently described complication of malignant lymphoma. A patient with nodular, poorly differentiated lymphocytic lymphoma (a B-cell neoplasm) had a notable alteration in mental status. Examination of the CSF showed characteristic cryptococcal organisms, but also was believed to demonstrate CNS involvement with lymphoma. A T-cell rosetting assay proved clinically useful by identifying the atypical lymphocytes as T cells rather than neoplastic B cells.

AB - Cryptococcal meningitis is a frequently described complication of malignant lymphoma. A patient with nodular, poorly differentiated lymphocytic lymphoma (a B-cell neoplasm) had a notable alteration in mental status. Examination of the CSF showed characteristic cryptococcal organisms, but also was believed to demonstrate CNS involvement with lymphoma. A T-cell rosetting assay proved clinically useful by identifying the atypical lymphocytes as T cells rather than neoplastic B cells.

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Cryptococcal meningitis with false-positive cytology in the CSF. Use of T-cell rosetting to exclude meningeal lymphoma

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