Cryptococcal meningitis diagnostics and screening in the era of point-of-care laboratory testing

Radha Rajasingham, Rachel M. Wake, Tafese Beyene, Andrew Katende, Emilio Letang, David R. Boulware

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg), with the recent development and distribution of a point-of-care lateral flow assay. This assay is highly sensitive and specific in cerebrospinal fluid (CSF), but is also sensitive in the blood to detect CrAg prior to meningitis symptoms. CrAg screening of HIV-infected persons in the blood prior to development of fulminant meningitis and preemptive treatment for CrAg-positive persons are recommended by the World Health Organization and many national HIV guidelines. Thus, CrAg testing is occurring more widely, especially in resource-limited laboratory settings. CrAg titer predicts meningitis and death and could be used in the future to customize therapy according to burden of infection.

Original languageEnglish (US)
Article numbere01238
JournalJournal of clinical microbiology
Issue number1
StatePublished - Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 American Society for Microbiology. All Rights Reserved.


  • Cryptococcus
  • Diagnostics
  • Point-of-care
  • Prevention


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