Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Jayne Ellis; Fiona V. Cresswell; Joshua Rhein; Kenneth Ssebambulidde; David R. Boulware

doi:10.1093/ofid/ofy193

Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Jayne Ellis, Fiona V. Cresswell, Joshua Rhein, Kenneth Ssebambulidde, David R. Boulware

Medicine - Infectious Disease and International Medicine

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25 Scopus citations

Abstract

We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofy193
State	Published - Aug 1 2018

Bibliographical note

Publisher Copyright:
© The Author(s) 2018.

Keywords

Case series
Cryptococcal meningitis
HIV/ AIDS
Tuberculosis
Tuberculous meningitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults",

abstract = "We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.",

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AU - Cresswell, Fiona V.

AU - Rhein, Joshua

AU - Ssebambulidde, Kenneth

AU - Boulware, David R.

N1 - Publisher Copyright: © The Author(s) 2018.

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Y1 - 2018/8/1

N2 - We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.

AB - We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.

KW - Case series

KW - Cryptococcal meningitis

KW - HIV/ AIDS

KW - Tuberculosis

KW - Tuberculous meningitis

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Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Abstract

Bibliographical note

Keywords

UN SDGs

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