Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Jayne Ellis; Fiona V. Cresswell; Joshua Rhein; Kenneth Ssebambulidde; David R. Boulware

doi:10.1093/ofid/ofy193

Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Jayne Ellis, Fiona V. Cresswell, Joshua Rhein, Kenneth Ssebambulidde, David R. Boulware

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofy193
State	Published - Aug 1 2018

Bibliographical note

Funding Information:
Financial support. This work was supported by the National Institute of Neurologic Diseases and Stroke (R01NS086312), the Fogarty International Center (K01TW010268, R25TW009345), the National Institute of Allergy and Infectious Diseases (T32AI055433), the United Kingdom Medical Research Council/DfID/Wellcome Trust Global Clinical Trials (M007413/1), and the Wellcome Trust (210772/Z/18/Z). We thank the University of Minnesota Foundation for provision of the Bactec MGIT culture system for the MSF Epicentre laboratory in Mbarara, Uganda.

Publisher Copyright:
© The Author(s) 2018.

Keywords

Case series
Cryptococcal meningitis
HIV/ AIDS
Tuberculosis
Tuberculous meningitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofy193

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title = "Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults",

abstract = "We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.",

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note = "Funding Information: Financial support. This work was supported by the National Institute of Neurologic Diseases and Stroke (R01NS086312), the Fogarty International Center (K01TW010268, R25TW009345), the National Institute of Allergy and Infectious Diseases (T32AI055433), the United Kingdom Medical Research Council/DfID/Wellcome Trust Global Clinical Trials (M007413/1), and the Wellcome Trust (210772/Z/18/Z). We thank the University of Minnesota Foundation for provision of the Bactec MGIT culture system for the MSF Epicentre laboratory in Mbarara, Uganda. Publisher Copyright: {\textcopyright} The Author(s) 2018.",

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AU - Rhein, Joshua

AU - Ssebambulidde, Kenneth

AU - Boulware, David R.

N1 - Funding Information: Financial support. This work was supported by the National Institute of Neurologic Diseases and Stroke (R01NS086312), the Fogarty International Center (K01TW010268, R25TW009345), the National Institute of Allergy and Infectious Diseases (T32AI055433), the United Kingdom Medical Research Council/DfID/Wellcome Trust Global Clinical Trials (M007413/1), and the Wellcome Trust (210772/Z/18/Z). We thank the University of Minnesota Foundation for provision of the Bactec MGIT culture system for the MSF Epicentre laboratory in Mbarara, Uganda. Publisher Copyright: © The Author(s) 2018.

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Y1 - 2018/8/1

N2 - We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.

AB - We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.

KW - Case series

KW - Cryptococcal meningitis

KW - HIV/ AIDS

KW - Tuberculosis

KW - Tuberculous meningitis

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Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Abstract

Bibliographical note

Keywords

UN SDGs

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