Cryogenic electron microscopy study of nanoemulsion formation from microemulsions

Han Seung Lee, Eric D. Morrison, Chris D. Frethem, Joseph A. Zasadzinski, Alon V. McCormick

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We examine a process of preparing oil-in-water nanoemulsions by quenching (diluting and cooling) precursor microemulsions made with nonionic surfactants and a cosurfactant. The precursor microemulsion structure is varied by changing the concentration of the cosurfactant. Water-continuous microemulsions produce initial nanoemulsion structures that are small and simple, mostly unilamellar vesicles, but microemulsions that are not water-continuous produce initial nanoemulsion structures that are larger and multilamellar. Examination of these structures by cryoelectron microscopy supports the hypothesis that they are initially vesicular structures formed via lamellar intermediate structures, and that if the lamellar structures are too well ordered they fail to produce small simple structures.

Original languageEnglish (US)
Pages (from-to)10826-10833
Number of pages8
JournalLangmuir
Volume30
Issue number36
DOIs
StatePublished - Sep 16 2014

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