The results from the second run of the Cryogenic Dark Matter Search experiment in the Soudan Underground Laboratory yields new exclusion limits on the coherent WIMPnucleon scalar cross-sections for WIMP masses above 15 GeV/c2. Two towers, each consisting of six detectors, were operated in the mine for 74.5 live days, doubling the previous Ge exposure to 34 kg-d after cuts for recoil energies of 10-100 keV. When combined with the data from the first run at Soudan, the new upper limit is 1.6 × 10-43 cm2 for a 60 GeV WIMP using the standard dark-matter halo and nuclear physics WIMP model. This is a factor of 2.5 lower than our previous limit and a factor of 10 lower than any other experiment. Limits from the Si data (12 kg-d) are less stringent, but extend the excluded region for low mass WIMPs. CDMS also has sensitivity to spin-dependent limits.