Abstract
Beyond the major metabolic connections that make up the framework of the metabolic network is metabolic crosstalk, which is the subtle interactions between discrete metabolic processes/pathways. These interactions, which are mediated by metabolites and proteins, coordinate metabolic processes to produce a robust metabolic network. Crosstalk interactions can be identified genetically in vivo and are further characterized with a cross-disciplinary approach. Probing metabolic crosstalk aids in characterizing genes of unknown function and revealing the next tier of metabolic paradigms.
Original language | English (US) |
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Title of host publication | Brenner's Encyclopedia of Genetics |
Subtitle of host publication | Second Edition |
Publisher | Elsevier Inc. |
Pages | 231-233 |
Number of pages | 3 |
ISBN (Electronic) | 9780080961569 |
ISBN (Print) | 9780123749840 |
DOIs | |
State | Published - Feb 27 2013 |
Externally published | Yes |
Keywords
- Biosynthesis
- Crosstalk
- Evolvability
- Genetics
- Metabolic integration
- Metabolic pathway
- Metabolism
- Microbiology
- Redundancy
- Regulation
- Suppressor analysis