Jannell V Bazurto, D. M. Downs

Research output: Chapter in Book/Report/Conference proceedingChapter


Beyond the major metabolic connections that make up the framework of the metabolic network is metabolic crosstalk, which is the subtle interactions between discrete metabolic processes/pathways. These interactions, which are mediated by metabolites and proteins, coordinate metabolic processes to produce a robust metabolic network. Crosstalk interactions can be identified genetically in vivo and are further characterized with a cross-disciplinary approach. Probing metabolic crosstalk aids in characterizing genes of unknown function and revealing the next tier of metabolic paradigms.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
StatePublished - Feb 27 2013
Externally publishedYes


  • Biosynthesis
  • Crosstalk
  • Evolvability
  • Genetics
  • Metabolic integration
  • Metabolic pathway
  • Metabolism
  • Microbiology
  • Redundancy
  • Regulation
  • Suppressor analysis


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