Abstract
Embryonic septal and hippocampal tissue from mice was transplanted between species into the brains of adult rat hosts as cell suspensions. Deficits in the ability to learn a conditioned, hippocampally mediated, forced alternation behavior, which were caused by a bilateral transection of the fornix-fimbria pathway, were ameliorated in the septal transplant recipients. The successful performance of the task was correlated to the density index of acetylcholinesterase in the hippocampal section.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 176-180 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 346 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 28 1985 |
Bibliographical note
Funding Information:We acknowledge the contributions of Drs. P.R. Hoffman, L.F. Kromer and W. Halpern. Research supported by PHS Grant 5429-17-3 and a summer Grass Foundation Fellowship to R.P.B.
Keywords
- acetylcholinesterase
- conditioned behavior
- hippocampal transplant
- septal transplant
Fingerprint
Dive into the research topics of 'Cross-species embryonic septal transplants: restoration of conditioned learning behavior'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS