Cross-species embryonic septal transplants: restoration of conditioned learning behavior

J. K. Daniloff; R. P. Bodony; W. C. Low; Josehh Wells

doi:10.1016/0006-8993(85)91112-6

Cross-species embryonic septal transplants: restoration of conditioned learning behavior

J. K. Daniloff, R. P. Bodony, W. C. Low, Josehh Wells

Neurosurgery

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39 Scopus citations

Abstract

Embryonic septal and hippocampal tissue from mice was transplanted between species into the brains of adult rat hosts as cell suspensions. Deficits in the ability to learn a conditioned, hippocampally mediated, forced alternation behavior, which were caused by a bilateral transection of the fornix-fimbria pathway, were ameliorated in the septal transplant recipients. The successful performance of the task was correlated to the density index of acetylcholinesterase in the hippocampal section.

Original language	English (US)
Pages (from-to)	176-180
Number of pages	5
Journal	Brain Research
Volume	346
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(85)91112-6
State	Published - Oct 28 1985

Bibliographical note

Funding Information:
We acknowledge the contributions of Drs. P.R. Hoffman, L.F. Kromer and W. Halpern. Research supported by PHS Grant 5429-17-3 and a summer Grass Foundation Fellowship to R.P.B.

Keywords

acetylcholinesterase
conditioned behavior
hippocampal transplant
septal transplant

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10.1016/0006-8993(85)91112-6

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abstract = "Embryonic septal and hippocampal tissue from mice was transplanted between species into the brains of adult rat hosts as cell suspensions. Deficits in the ability to learn a conditioned, hippocampally mediated, forced alternation behavior, which were caused by a bilateral transection of the fornix-fimbria pathway, were ameliorated in the septal transplant recipients. The successful performance of the task was correlated to the density index of acetylcholinesterase in the hippocampal section.",

keywords = "acetylcholinesterase, conditioned behavior, hippocampal transplant, septal transplant",

author = "Daniloff, {J. K.} and Bodony, {R. P.} and Low, {W. C.} and Josehh Wells",

note = "Funding Information: We acknowledge the contributions of Drs. P.R. Hoffman, L.F. Kromer and W. Halpern. Research supported by PHS Grant 5429-17-3 and a summer Grass Foundation Fellowship to R.P.B.",

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AU - Daniloff, J. K.

AU - Bodony, R. P.

AU - Low, W. C.

AU - Wells, Josehh

N1 - Funding Information: We acknowledge the contributions of Drs. P.R. Hoffman, L.F. Kromer and W. Halpern. Research supported by PHS Grant 5429-17-3 and a summer Grass Foundation Fellowship to R.P.B.

PY - 1985/10/28

Y1 - 1985/10/28

N2 - Embryonic septal and hippocampal tissue from mice was transplanted between species into the brains of adult rat hosts as cell suspensions. Deficits in the ability to learn a conditioned, hippocampally mediated, forced alternation behavior, which were caused by a bilateral transection of the fornix-fimbria pathway, were ameliorated in the septal transplant recipients. The successful performance of the task was correlated to the density index of acetylcholinesterase in the hippocampal section.

AB - Embryonic septal and hippocampal tissue from mice was transplanted between species into the brains of adult rat hosts as cell suspensions. Deficits in the ability to learn a conditioned, hippocampally mediated, forced alternation behavior, which were caused by a bilateral transection of the fornix-fimbria pathway, were ameliorated in the septal transplant recipients. The successful performance of the task was correlated to the density index of acetylcholinesterase in the hippocampal section.

KW - acetylcholinesterase

KW - conditioned behavior

KW - hippocampal transplant

KW - septal transplant

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Cross-species embryonic septal transplants: restoration of conditioned learning behavior

Abstract

Bibliographical note

Keywords

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