Cross-species embryonic septal transplants: restoration of conditioned learning behavior

J. K. Daniloff, R. P. Bodony, W. C. Low, Josehh Wells

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Embryonic septal and hippocampal tissue from mice was transplanted between species into the brains of adult rat hosts as cell suspensions. Deficits in the ability to learn a conditioned, hippocampally mediated, forced alternation behavior, which were caused by a bilateral transection of the fornix-fimbria pathway, were ameliorated in the septal transplant recipients. The successful performance of the task was correlated to the density index of acetylcholinesterase in the hippocampal section.

Original languageEnglish (US)
Pages (from-to)176-180
Number of pages5
JournalBrain Research
Issue number1
StatePublished - Oct 28 1985

Bibliographical note

Funding Information:
We acknowledge the contributions of Drs. P.R. Hoffman, L.F. Kromer and W. Halpern. Research supported by PHS Grant 5429-17-3 and a summer Grass Foundation Fellowship to R.P.B.


  • acetylcholinesterase
  • conditioned behavior
  • hippocampal transplant
  • septal transplant


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