Embryonic septal and hippocampal tissue from mice was transplanted between species into the brains of adult rat hosts as cell suspensions. Deficits in the ability to learn a conditioned, hippocampally mediated, forced alternation behavior, which were caused by a bilateral transection of the fornix-fimbria pathway, were ameliorated in the septal transplant recipients. The successful performance of the task was correlated to the density index of acetylcholinesterase in the hippocampal section.
Bibliographical noteFunding Information:
We acknowledge the contributions of Drs. P.R. Hoffman, L.F. Kromer and W. Halpern. Research supported by PHS Grant 5429-17-3 and a summer Grass Foundation Fellowship to R.P.B.
- conditioned behavior
- hippocampal transplant
- septal transplant