Cross-sectional study of sex differences in psychosocial quality of life of long-term melanoma survivors

Rachel I. Vogel, Broderick Yoerg, Patricia I. Jewett, Nathan Rubin, Megan Olson, Ashley E. Stenzel, Rehana L. Ahmed, De Ann Lazovich

Research output: Contribution to journalArticlepeer-review


PURPOSE: A cancer diagnosis and subsequent treatment can have a significant impact on an individual's quality of life. Differences in quality of life by sex among long-term melanoma survivors remain unclear. The objective of this study was to describe sex differences in cancer-specific psychosocial quality of life of long-term melanoma survivors.

METHODS: Melanoma survivors 7-10 years post-diagnosis from a previously conducted population-based case-control study were recruited for a cross-sectional survey. Validated measures of psychosocial quality of life related to melanoma diagnosis were assessed. Outcomes were compared by sex using linear regression models adjusting for age, education, income, and marital status.

RESULTS: The survey response rate was 62% (433 females, 291 males; 86% stage I disease). Females were more likely to report changes in their appearance (p = 0.006) and being more fearful of recurrence (p = 0.001) or a second melanoma (p = 0.001) than males but were also more likely to report that melanoma had a positive impact on their lives (p < 0.0001). Males were more likely to agree with statements that emphasized that life's duration is limited (p < 0.0001).

CONCLUSION: Long-term melanoma survivors reported generally favorable measures of psychosocial quality of life related to their diagnosis. Females and males reported unique quality of life concerns and may require varied methods of support following a melanoma diagnosis.

Original languageEnglish (US)
Pages (from-to)5663-5671
Number of pages9
JournalSupportive Care in Cancer
Issue number10
Early online dateFeb 12 2021
StatePublished - Oct 2021

Bibliographical note

Funding Information:
This work was supported by a grant from the Masonic Cancer Center of the University of Minnesota’s internal grants program (Lazovich), National Cancer Institute, National Institutes of Health, grant P30 CA77598 (PI: Yee) utilizing the Biostatistics Core, a shared resource of the Masonic Cancer Center (Vogel), and National Center for Advancing Translational Sciences of the National Institutes of Health grant UL1TR002494 (PI: Blazar) for utilization of REDCap (Vogel). Work on this manuscript was additionally supported by the Wayne Stinchcomb Big Orange Foundation-Melanoma Research Alliance Young Investigator Award (Vogel) and National Cancer Institute, National Institutes of Health grant T32CA163184 (Stenzel). The funders had no role in the design of the study and collection, analysis, or interpretation of data and in writing the manuscript.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.


  • Cancer survivorship
  • Melanoma
  • Quality of life
  • Sex differences


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