Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women

Talia N. Crawford; Andrea Y. Arikawa; Mindy S. Kurzer; Kathryn H. Schmitz; William R. Phipps

doi:10.1016/j.fertnstert.2015.08.040

Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women

Talia N. Crawford, Andrea Y. Arikawa, Mindy S. Kurzer, Kathryn H. Schmitz, William R. Phipps

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective To assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women. Design Cross-sectional study. Setting University general clinical research center. Subject(s) A total of 319 young healthy women with ovulatory menstrual cycles. Intervention(s) None. Main Outcome Measure(s) Midfollicular serum SHBG concentrations. Result(s) In our final linear regression model, SHBG was negatively associated with bioavailable T and positively associated with adiponectin, associations that were independent from other parameters. SHBG was also positively associated with estrone sulfate, but only when taking into account confounding variables. Unexpectedly, there was no straightforward relationship between SHBG and insulin resistance according to homeostasis-model assessment. Conclusion(s) Our results highlight the link between androgen action, as reflected by bioavailable T, and circulating SHBG concentrations in all premenopausal women and speak to the importance of the relationship between SHBG and adiponectin, which is at least in part independent from androgen action. Clinical Trial Registration Number NCT00393172.

Original language	English (US)
Pages (from-to)	1544-1551
Number of pages	8
Journal	Fertility and Sterility
Volume	104
Issue number	6
DOIs	https://doi.org/10.1016/j.fertnstert.2015.08.040
State	Published - 2015

Bibliographical note

Funding Information:
Supported by National Institutes of Health/National Cancer Institute grant 1U54CA116849-010003. The WISER study was funded by National Institutes of Health/National Cancer Institute grant 1U54CA116849-010003, Department of Defense/United States Army Medical Research and Materiel Command Congressionally Directed Medical Research Programs award no. W81XWH-08-1-0301, and National Institutes of Health/National Center for Research Resources grant M01-RR00400. The authors acknowledge the General Clinical Research Center at the University of Minnesota, the study administrative staff, and study participants.

Publisher Copyright:
© 2015 American Society for Reproductive Medicine. Published by Elsevier Inc.

Keywords

Sex hormone-binding globulin
adiponectin
insulin resistance
premenopause
testosterone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fertnstert.2015.08.040

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title = "Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women",

abstract = "Objective To assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women. Design Cross-sectional study. Setting University general clinical research center. Subject(s) A total of 319 young healthy women with ovulatory menstrual cycles. Intervention(s) None. Main Outcome Measure(s) Midfollicular serum SHBG concentrations. Result(s) In our final linear regression model, SHBG was negatively associated with bioavailable T and positively associated with adiponectin, associations that were independent from other parameters. SHBG was also positively associated with estrone sulfate, but only when taking into account confounding variables. Unexpectedly, there was no straightforward relationship between SHBG and insulin resistance according to homeostasis-model assessment. Conclusion(s) Our results highlight the link between androgen action, as reflected by bioavailable T, and circulating SHBG concentrations in all premenopausal women and speak to the importance of the relationship between SHBG and adiponectin, which is at least in part independent from androgen action. Clinical Trial Registration Number NCT00393172.",

keywords = "Sex hormone-binding globulin, adiponectin, insulin resistance, premenopause, testosterone",

author = "Crawford, {Talia N.} and Arikawa, {Andrea Y.} and Kurzer, {Mindy S.} and Schmitz, {Kathryn H.} and Phipps, {William R.}",

note = "Funding Information: Supported by National Institutes of Health/National Cancer Institute grant 1U54CA116849-010003. The WISER study was funded by National Institutes of Health/National Cancer Institute grant 1U54CA116849-010003, Department of Defense/United States Army Medical Research and Materiel Command Congressionally Directed Medical Research Programs award no. W81XWH-08-1-0301, and National Institutes of Health/National Center for Research Resources grant M01-RR00400. The authors acknowledge the General Clinical Research Center at the University of Minnesota, the study administrative staff, and study participants. Publisher Copyright: {\textcopyright} 2015 American Society for Reproductive Medicine. Published by Elsevier Inc.",

year = "2015",

doi = "10.1016/j.fertnstert.2015.08.040",

language = "English (US)",

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AU - Crawford, Talia N.

AU - Arikawa, Andrea Y.

AU - Kurzer, Mindy S.

AU - Schmitz, Kathryn H.

AU - Phipps, William R.

N1 - Funding Information: Supported by National Institutes of Health/National Cancer Institute grant 1U54CA116849-010003. The WISER study was funded by National Institutes of Health/National Cancer Institute grant 1U54CA116849-010003, Department of Defense/United States Army Medical Research and Materiel Command Congressionally Directed Medical Research Programs award no. W81XWH-08-1-0301, and National Institutes of Health/National Center for Research Resources grant M01-RR00400. The authors acknowledge the General Clinical Research Center at the University of Minnesota, the study administrative staff, and study participants. Publisher Copyright: © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc.

PY - 2015

Y1 - 2015

N2 - Objective To assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women. Design Cross-sectional study. Setting University general clinical research center. Subject(s) A total of 319 young healthy women with ovulatory menstrual cycles. Intervention(s) None. Main Outcome Measure(s) Midfollicular serum SHBG concentrations. Result(s) In our final linear regression model, SHBG was negatively associated with bioavailable T and positively associated with adiponectin, associations that were independent from other parameters. SHBG was also positively associated with estrone sulfate, but only when taking into account confounding variables. Unexpectedly, there was no straightforward relationship between SHBG and insulin resistance according to homeostasis-model assessment. Conclusion(s) Our results highlight the link between androgen action, as reflected by bioavailable T, and circulating SHBG concentrations in all premenopausal women and speak to the importance of the relationship between SHBG and adiponectin, which is at least in part independent from androgen action. Clinical Trial Registration Number NCT00393172.

AB - Objective To assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women. Design Cross-sectional study. Setting University general clinical research center. Subject(s) A total of 319 young healthy women with ovulatory menstrual cycles. Intervention(s) None. Main Outcome Measure(s) Midfollicular serum SHBG concentrations. Result(s) In our final linear regression model, SHBG was negatively associated with bioavailable T and positively associated with adiponectin, associations that were independent from other parameters. SHBG was also positively associated with estrone sulfate, but only when taking into account confounding variables. Unexpectedly, there was no straightforward relationship between SHBG and insulin resistance according to homeostasis-model assessment. Conclusion(s) Our results highlight the link between androgen action, as reflected by bioavailable T, and circulating SHBG concentrations in all premenopausal women and speak to the importance of the relationship between SHBG and adiponectin, which is at least in part independent from androgen action. Clinical Trial Registration Number NCT00393172.

KW - Sex hormone-binding globulin

KW - adiponectin

KW - insulin resistance

KW - premenopause

KW - testosterone

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Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women

Abstract

Bibliographical note

Keywords

UN SDGs

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