TY - JOUR
T1 - Cross-National Diagnosis of Schizophrenia in Twins
T2 - The Heritability and Specificity of Schizophrenia
AU - Shields, James
AU - Gottesman, Irving I.
PY - 1972/12
Y1 - 1972/12
N2 - An international panel of seven diagnosticians from Japan, Sweden, the United Kingdom, and the United States blindly diagnosed the histories of the 114 twins in the Maudsley schizophrenic twin series. The middle-of-the-road consensus diagnosis of schizophrenia was easily reached. Besides being more reliable, it gave better monozygotic to dizygotic (MZ:DZ) discrimination than attempts to apply broader or narrower diagnostic criteria. A similar standard applied to the other recent schizophrenic twin studies secured reasonable agreement, and the pooled MZ concordance rate from the studies was 46%, higher than sometimes reported. The study vindicates both the diagnosis of schizophrenia and its substantial heritability.
AB - An international panel of seven diagnosticians from Japan, Sweden, the United Kingdom, and the United States blindly diagnosed the histories of the 114 twins in the Maudsley schizophrenic twin series. The middle-of-the-road consensus diagnosis of schizophrenia was easily reached. Besides being more reliable, it gave better monozygotic to dizygotic (MZ:DZ) discrimination than attempts to apply broader or narrower diagnostic criteria. A similar standard applied to the other recent schizophrenic twin studies secured reasonable agreement, and the pooled MZ concordance rate from the studies was 46%, higher than sometimes reported. The study vindicates both the diagnosis of schizophrenia and its substantial heritability.
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U2 - 10.1001/archpsyc.1972.01750300005001
DO - 10.1001/archpsyc.1972.01750300005001
M3 - Article
C2 - 4637890
AN - SCOPUS:0015453001
SN - 0003-990X
VL - 27
SP - 725
EP - 730
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 6
ER -