Cross-linking of the DNA repair protein O⁶-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards

Keyphrases

• DNA Repair Enzymes 100%
• Antitumor 100%
• O6-methylguanine-DNA Methyltransferase 100%
• Nitrogen mustard 100%
• Guanine 62%
• Ethyl 50%
• Chlorambucil 50%
• Mechlorethamine 50%
• DNA Interstrand Crosslinks 37%
• Antitumor Activity 25%
• Electrospray Ionization Mass Spectrometry 25%
• Mustard 25%
• Recombinant Human 12%
• Nuclear Proteins 12%
• Control Cell 12%
• Protein Hydrolysate 12%
• Protein Active Site 12%
• Protein Cross-linking 12%
• Protein-DNA Complex 12%
• Cytotoxicity 12%
• Cyclophosphamide 12%
• Double Strand 12%
• Alkylation 12%
• Oligodeoxynucleotide 12%
• Mass Spectrometry Analysis 12%
• Tryptic Peptides 12%
• Chemical Structure 12%
• Double mutant 12%
• Tumor Subtype 12%
• HPLC-ESI-MS 12%
• Capillary HPLC 12%
• DNA Duplex 12%
• Methylamine 12%
• Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) 12%
• Cross-linked 12%
• DNA Conjugation 12%
• Binding Residues 12%
• Protein Extract 12%
• High Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) 12%
• CHO Cells 12%
• Mutagenic Activity 12%
• LC-MS Analysis 12%
• Melphalan 12%
• Nucleophilic Site 12%
• Covalent Conjugate 12%
• DNA-peptide Conjugates 12%
• Single-point mutation 12%
• Amino Acid Conjugation 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Nitrogen Mustard 100%
• 6 O Alkylguanine DNA Alkyltransferase 100%
• Guanine 41%
• Chlorambucil 33%
• High Performance Liquid Chromatography 25%
• Deoxyribonucleoprotein 16%
• Antitumor Activity 8%
• Protein Characterization 8%
• Amino Acid 8%
• Cyclophosphamide 8%
• Phosphorus 32 8%
• Double Stranded DNA 8%
• Oligodeoxynucleotide 8%
• Melphalan 8%
• Methylamine 8%
• Neoplasm 8%
• Electrospray Ionization 8%
• Polyacrylamide Gel Electrophoresis 8%
• Nuclear Protein 8%
• Protein Hydrolysate 8%
• Cytotoxicity 8%