Cross-linkage of hydroxyapatite/gelatin nanocomposite using imide-based zero-length cross-linker

Myung Chul Chang, William H. Douglas

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38 Scopus citations


Hydroxyapatite [HAp]/Gelatin [GEL] nanocomposite was prepared at 37 and 48°C through coprecipitation process. The HAp/GEL nanocomposite slurries were cross-linked by imide-based zero-length cross-linking agent such as N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS). The chemical bond formation and microstructure in HAp/GEL nanocomposite was investigated as a function of cross-linking agents and temperature. The single addition of EDC into the composite slurries resulted in a tougher microstructure in both samples prepared at 37 and 48°C. However, in the case of the simultaneous addition of EDC and NHS the sample prepared at 48°C showed a coarse microstructure. These results were consistent with the fact that the chemical reactivity of NHS is degraded at 48°C whereas the reactivity of EDC increases up to 80°C.

Original languageEnglish (US)
Pages (from-to)2045-2051
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Issue number10
StatePublished - Oct 2007

Bibliographical note

Funding Information:
Acknowledgment The authors thank Mr. Jae Yong Chang for his assistance in the preparation of samples. This study was partially supported by MDRCBB and 3MESPE Dental Products.


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