Cross-genome knowledge-based expression data fusion

Matěj Holec; Jiří Kléma; Filip Železný; Jiří Bělohradský; Jakub Tolar

Cross-genome knowledge-based expression data fusion

Matěj Holec, Jiří Kléma, Filip Železný, Jiří Bělohradský, Jakub Tolar

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper presents the web tool XGENE.ORG which facilitates the integration of gene expression measurements with background genomic information, in particular the gene ontology and KEGG pathways. The novelty of the proposed data fusion is in the introduction of working units at different levels of generality acting as sample features, replacing the commonly used gene units, consequently allowing for cross-genome (multi-platform) expression data analysis. The integration of different microarray platforms contributes to the robustness of knowledge extracted when single-platform samples are rare and facilitates inference of biological knowledge not constrained to single organisms. Copyright

Original language	English (US)
Title of host publication	International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009
Pages	43-50
Number of pages	8
State	Published - Dec 1 2009
Event	2009 International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics, BCBGC 2009 - Orlando, FL, United States Duration: Jul 13 2009 → Jul 16 2009

Publication series

Name	International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009

Other

Other	2009 International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics, BCBGC 2009
Country/Territory	United States
City	Orlando, FL
Period	7/13/09 → 7/16/09

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Holec, M., Kléma, J., Železný, F., Bělohradský, J., & Tolar, J. (2009). Cross-genome knowledge-based expression data fusion. In International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009 (pp. 43-50). (International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009).

Cross-genome knowledge-based expression data fusion. / Holec, Matěj; Kléma, Jiří; Železný, Filip et al.
International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009. 2009. p. 43-50 (International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Holec, M, Kléma, J, Železný, F, Bělohradský, J & Tolar, J 2009, Cross-genome knowledge-based expression data fusion. in International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009. International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009, pp. 43-50, 2009 International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics, BCBGC 2009, Orlando, FL, United States, 7/13/09.

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AU - Kléma, Jiří

AU - Železný, Filip

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AU - Tolar, Jakub

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AB - This paper presents the web tool XGENE.ORG which facilitates the integration of gene expression measurements with background genomic information, in particular the gene ontology and KEGG pathways. The novelty of the proposed data fusion is in the introduction of working units at different levels of generality acting as sample features, replacing the commonly used gene units, consequently allowing for cross-genome (multi-platform) expression data analysis. The integration of different microarray platforms contributes to the robustness of knowledge extracted when single-platform samples are rare and facilitates inference of biological knowledge not constrained to single organisms. Copyright

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M3 - Conference contribution

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BT - International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009, BCBGC 2009

T2 - 2009 International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics, BCBGC 2009

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ER -

Cross-genome knowledge-based expression data fusion

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