Cromolyn in extrinsic and intrinsic asthma

M. N. Blumenthal, W. F. Schoenwetter, F. M. MacDonald, R. B. McHugh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cromolyn sodium was evaluated in 30 patients with intrinsic bronchial asthma and in 29 patients with extrinsic bronchial asthma using a double-blind crossover method. Each patient was studied during a base line, placebo, and cromolyn period. Daily evaluation was performed with regard to upper respiratory tract symptoms, lower respiratory tract symptoms, oral medication scores, use of sympathomimetic agents by aerosolization and peak expiratory flow rates measured 5 times a day. Weekly evaluation consisted of a physician's evaluation and a timed vital capacity. At the end of each test period spirometry, airway resistance and an exercise tolerance test were performed. Evaluation of the intrinsic asthmatic patients revealed significant improvement during the cromolyn period as compared to the placebo and base line periods with regard to the daily recorded variables and the physician's evaluation. Study of the other parameters showed no significant trend. Evaluation of the use of cromolyn in extrinsic bronchial asthma revealed no general trends for any of the parameters measured.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalThe Journal of Allergy and Clinical Immunology
Volume52
Issue number2
DOIs
StatePublished - Jan 1 1973

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Cromolyn Sodium
Asthma
Respiratory System
Placebos
Physicians
Peak Expiratory Flow Rate
Sympathomimetics
Airway Resistance
Exercise Tolerance
Spirometry
Forced Expiratory Volume
Exercise Test
Double-Blind Method

Cite this

Blumenthal, M. N., Schoenwetter, W. F., MacDonald, F. M., & McHugh, R. B. (1973). Cromolyn in extrinsic and intrinsic asthma. The Journal of Allergy and Clinical Immunology, 52(2), 105-114. https://doi.org/10.1016/0091-6749(73)90082-1

Cromolyn in extrinsic and intrinsic asthma. / Blumenthal, M. N.; Schoenwetter, W. F.; MacDonald, F. M.; McHugh, R. B.

In: The Journal of Allergy and Clinical Immunology, Vol. 52, No. 2, 01.01.1973, p. 105-114.

Research output: Contribution to journalArticle

Blumenthal, MN, Schoenwetter, WF, MacDonald, FM & McHugh, RB 1973, 'Cromolyn in extrinsic and intrinsic asthma', The Journal of Allergy and Clinical Immunology, vol. 52, no. 2, pp. 105-114. https://doi.org/10.1016/0091-6749(73)90082-1
Blumenthal, M. N. ; Schoenwetter, W. F. ; MacDonald, F. M. ; McHugh, R. B. / Cromolyn in extrinsic and intrinsic asthma. In: The Journal of Allergy and Clinical Immunology. 1973 ; Vol. 52, No. 2. pp. 105-114.
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