Crk and CrkL adaptor proteins: Networks for physiological and pathological signaling

Raymond B. Birge, Charalampos Kalodimos, Fuyuhiko Inagaki, Shinya Tanaka

Research output: Contribution to journalReview articlepeer-review

224 Scopus citations


The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses.

Original languageEnglish (US)
Article number13
JournalCell Communication and Signaling
StatePublished - 2009
Externally publishedYes


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